Pharmacokinetics and Bioavailability of Herbal Formulations for Diabetes Management

DOI: https://doi.org/10.63345/ijrmp.org.v8.i8.1

Shreya Chaudhary

Independent Researcher

Uttar Pradesh, India

Abstract

Diabetes mellitus is a multifactorial metabolic disorder characterized by chronic hyperglycemia and associated with severe complications. In recent decades, herbal formulations have emerged as promising alternatives or adjuncts to conventional therapies due to their multi-targeted actions and perceived safety profiles. However, understanding their pharmacokinetic behavior and bioavailability is critical to optimizing their therapeutic potential. This manuscript reviews the current state of knowledge regarding the pharmacokinetics and bioavailability of herbal formulations used in diabetes management. A detailed literature review up to the year 2018 is provided, summarizing the mechanisms involved in absorption, distribution, metabolism, and excretion (ADME) of phytoconstituents. Furthermore, the challenges inherent in standardizing herbal extracts and improving their bioavailability through advanced formulation strategies are discussed. Finally, the study outlines a methodology for assessing pharmacokinetic parameters and reports preliminary results that highlight the variability in bioavailability among different herbal preparations. The conclusions underscore the necessity for further rigorous clinical investigations and the development of innovative drug delivery systems to enhance therapeutic efficacy in diabetes management.

Keywords

Herbal formulations; Pharmacokinetics; Bioavailability; Diabetes management; ADME; Phytoconstituents

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