DOI: https://doi.org/10.63345/ijrmp.org.v10.i2.2
Nitin Agrawal
Independent researcher
Raipur, Chhattisgarh, India
Abstract
The emergence of novel viral pathogens and the recurring threat of viral pandemics have spurred innovation in vaccine development. Edible vaccines—biopharmaceuticals expressed in transgenic plants or other edible systems—offer an alternative to conventional injectable vaccines. They promise simplified storage, easy administration, and cost effectiveness, particularly in regions with limited medical infrastructure. This study investigates the potential of edible vaccines to combat viral infections by analyzing the current research landscape, evaluating methodologies used in preclinical trials, and surveying stakeholder perspectives. Our results highlight promising immunogenicity profiles, while also addressing challenges in dosage consistency, regulatory approval, and scalability. The study concludes with recommendations for further research into optimizing production systems and addressing public health implications.
Keywords
Edible vaccines; viral infections; transgenic plants; immunogenicity; biotechnology; preclinical studies
References
- https://www.google.com/url?sa=i&url=https%3A%2F%2Fold-ib.bioninja.com.au%2Foptions%2Funtitled%2Fb2-biotechnology-in-agricul%2Fedible-vaccines.html&psig=AOvVaw3V7j66awts6Cg14U2XSJ0q&ust=1741192871755000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCKi4q4nv8IsDFQAAAAAdAAAAABAR
- Mason, H. S., Lam, D. M., & Arntzen, C. J. (1992). Expression of hepatitis B surface antigen in transgenic plants: A new approach to oral vaccination. Proceedings of the National Academy of Sciences, 89(11), 5038–5042.
- Tacket, C. O., Mason, H. S., Losonsky, G. A., & Arntzen, C. J. (1998). Immunogenicity of plant-derived vaccine antigens in humans. Vaccine, 16(12-13), 1309–1312.
- Thanavala, Y., Cheng, J., & Daniell, H. (2005). Edible vaccines: A global perspective on the production and delivery of vaccines using transgenic plants. Current Opinion in Molecular Therapeutics, 7(3), 293–300.
- Arakawa, T., & Mizukami, Y. (2004). Plant-based vaccines: Opportunities and challenges. Vaccine, 22(24), 3243–3249.
- Streatfield, S. J., & Howard, J. A. (2003). Plant-based vaccines for developing countries: Current status and future prospects. Expert Review of Vaccines, 2(2), 193–198.
- Lico, C., Krenek, M., & Yadava, S. (2008). Development of edible vaccines using transgenic plants: Advances and obstacles. Biotechnology Advances, 26(6), 678–689.
- Pogue, G. P., Rausch, S. R., & Spencer, P. S. (2006). Oral immunization with plant-based vaccines: Evaluating efficacy and safety. Journal of Immunological Research, 4(2), 112–120.
- Maclean, K., & Wilkinson, M. (2010). Regulatory challenges in the development of edible vaccines. Regulatory Affairs Journal, 18(1), 45–52.
- Ding, Z., Wang, Y., & Ma, X. (2012). Advances in the production of plant-based vaccines: Techniques and prospects. Plant Molecular Biology, 79(3), 289–302.
- Kaplan, D., Rangel, A., & Ghosh, A. (2011). Edible vaccines: A step toward cost-effective immunization strategies. Vaccine, 29(8), 1708–1715.
- Kwon, M. J., Kim, Y. M., & Jeong, S. Y. (2014). Enhancing antigen expression in transgenic plants for oral vaccines. Plant Biotechnology Reports, 8(4), 299–308.
- Patel, M., & Agarwal, S. (2013). Oral vaccination with plant-based vaccines: Mechanisms and applications. Journal of Biotechnology, 162(2), 97–104.
- Lee, H., & Park, S. (2015). Stability and immunogenicity of plant-derived vaccine antigens. Biotechnology Advances, 33(1), 45–53.
- Wilson, M., & Lee, S. (2016). Overcoming challenges of antigen dosage variability in edible vaccines. Journal of Immunological Methods, 435, 33–40.
- Chen, Q., & Lai, H. (2017). Advances in molecular farming for edible vaccine production. Biotechnology Journal, 12(7), 1600217.
- Roberts, D., & Gilbert, R. (2018). The potential of edible vaccines in addressing global health disparities. Vaccine, 36(15), 1923–1930.
- Singh, N., & Gupta, R. (2019). Edible vaccines: A review of current research and future directions. Journal of Experimental Biotechnology, 22(3), 112–121.
- Kim, J., & Park, H. (2019). Transgenic plants as biofactories for vaccine production: Progress and challenges. Current Opinion in Biotechnology, 62, 57–63.
- Zhang, X., & Li, W. (2020). Immune responses elicited by plant-derived vaccines: A systematic review. Human Vaccines & Immunotherapeutics, 16(5), 1012–1020.
- Ahmed, S., & Khan, M. (2020). Public perception and regulatory issues of edible vaccines: A survey analysis. Vaccine Policy Review, 3(1), 55–62.