DOI: https://doi.org/10.63345/ijrmp.v10.i11.4
Disha Patel
Independent Researcher
Maninagar, Gujarat, India
Abstract
Autoimmune disorders represent a complex and multifactorial class of diseases in which the immune system erroneously targets self-antigens. Traditional therapeutic approaches often center on immunosuppression, which carries inherent risks of broad immunodeficiency. Peptide-based vaccines have emerged as a novel therapeutic strategy aimed at restoring immune tolerance by precisely targeting pathogenic immune cells while sparing protective immune functions. This study investigates the potential of peptide-based vaccines to modulate autoimmune responses. We provide an in-depth review of literature available until 2020, describe our methodology—including immunoinformatics-based peptide selection, preclinical testing in animal models, and statistical analysis of immunological endpoints—and present preliminary results indicating a promising reduction in autoreactive T-cell frequencies and pro-inflammatory cytokines. Our findings support the further development of peptide-based vaccine strategies and provide insight into optimizing their design and delivery.
Keywords
Autoimmune disorders; peptide-based vaccine; immune tolerance; immunomodulation; cytokines; T-cell regulation; preclinical study
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