Investigating Biohybrid Implants for Smart Drug Release

Jhanvi Ramesh

Independent Researcher

Karnataka, India

Abstract

Biohybrid implants represent a novel convergence of biological and synthetic components to create dynamic, responsive drug delivery systems. These devices are engineered to achieve controlled, localized, and stimuli-responsive drug release by integrating living cells or biomolecules with biocompatible polymers and microelectromechanical systems (MEMS). The emergence of smart biohybrid implants addresses longstanding challenges in conventional drug delivery, such as non-specific distribution, burst release, and poor patient compliance. This study investigates the design, materials, mechanisms, and early clinical progress of biohybrid implants, with a focus on their responsiveness to physiological signals such as pH, temperature, and enzymatic activity. A comprehensive review of prior research, device architecture, and in vitro evaluations has been undertaken to determine the efficiency and reliability of these systems in achieving sustained drug release. The findings highlight the promise of biohybrid platforms in chronic disease management, particularly for conditions requiring localized and long-term pharmacological intervention.

Keywords

Biohybrid implants, smart drug delivery, microelectromechanical systems, stimuli-responsive release, biomaterials, controlled release systems

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