Aniket Basu
Independent Researcher
West Bengal, India
Abstract
Emerging research emphasizes the intricate communication between the gastrointestinal system and the central nervous system, commonly referred to as the gut-brain axis (GBA). In the context of neurodegenerative conditions such as Alzheimer’s disease (AD), the role of microbiota-mediated signaling has gained traction as a potential modifiable factor influencing disease progression. This study presents a longitudinal evaluation of gut-brain axis alterations in early-stage Alzheimer’s patients subjected to a Mediterranean diet (MD) over 12 months. The investigation explored changes in gut microbiome composition, circulating inflammatory markers, short-chain fatty acid (SCFA) production, and cognitive performance. Results indicated a significant association between the Mediterranean dietary pattern and reduced neuroinflammation, enhanced microbial diversity, and slower cognitive decline. This study reinforces the therapeutic potential of diet-based interventions in modulating GBA dynamics to delay Alzheimer’s progression.
Keywords
Alzheimer’s disease, gut-brain axis, Mediterranean diet, microbiome, neuroinflammation, cognitive function, SCFA, early-stage dementia, neurodegeneration, longitudinal study
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