Mohit Kapoor
Independent Researcher
Greater Noida, India
Abstract
The pursuit of reliable, human-relevant pharmacological testing platforms has catalyzed the development of bioengineered organs as alternatives to animal models and conventional in vitro systems. These artificial constructs emulate the structural, mechanical, and biochemical properties of native organs, offering unparalleled insights into drug absorption, distribution, metabolism, and toxicity (ADMET). The advent of tissue engineering, microfluidic technologies, and biomaterials science has enabled the creation of complex, organotypic models such as liver-on-a-chip, heart constructs, and kidney organoids. These systems have demonstrated substantial promise in preclinical drug screening, enabling predictive modeling of human responses with greater precision. This manuscript explores the key developments in bioengineered organ systems for pharmacological testing, highlighting their architecture, cell sourcing strategies, performance metrics, and relevance to translational medicine. The limitations of scalability, vascularization, and physiological integration are also discussed, laying the foundation for future enhancements in bioengineered test platforms.
Keywords
Bioengineered organs, pharmacological testing, organ-on-a-chip, drug screening, tissue engineering
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