Bioavailability Enhancement of Poorly Soluble Drugs Using Lipid Nanoparticles

DOI: https://doi.org/10.63345/ijrmp.v12.i2.3

Vikas Negi

Himachal Pradesh, India

Abstract

The challenge of poor water solubility remains a significant barrier in the pharmaceutical development of many drugs. Lipid nanoparticles have emerged as a promising carrier system to enhance the bioavailability of these drugs by improving solubilization, stability, and controlled release. This study examines the role of lipid nanoparticles in enhancing the bioavailability of poorly soluble drugs. Through a detailed literature review up to 2022 and an analysis of experimental data, we explore the formulation strategies, physicochemical characteristics, and in vitro/in vivo performance of lipid nanoparticle-based drug delivery systems. The results indicate that optimizing lipid composition and processing parameters leads to improved drug absorption and therapeutic outcomes. This paper discusses the potential applications, statistical analyses of formulation variables, and provides a detailed account of the methodology, results, and conclusions of the study. Ultimately, the study highlights both the promise and the challenges of translating lipid nanoparticle technology into clinical practice.

Keywords

Lipid Nanoparticles; Poorly Soluble Drugs; Bioavailability; Drug Delivery; Nanocarriers; Pharmacokinetics; Controlled Release

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