Development of Biodegradable Polymers for Controlled Drug Release

Er. Akshit Kohli

ABESIT Engineering College

Crossings Republik, Ghaziabad, Uttar Pradesh 201009

akshitkohli69@gmail.com

Abstract

Biodegradable polymers have emerged as an innovative platform for controlled drug release systems, offering significant advantages in terms of safety, efficacy, and patient compliance. This study investigates the synthesis, characterization, and application of novel biodegradable polymer matrices designed for the sustained release of therapeutic agents. By tailoring polymer composition and degradation profiles, the controlled release system ensures a consistent drug concentration over extended periods, thereby minimizing side effects and improving treatment outcomes. A comprehensive literature review up to 2017 was conducted to identify existing methodologies, limitations, and promising advancements. Statistical analyses were performed on in vitro release data, validating the consistency and reliability of the developed formulations. The results indicate that polymer modifications, such as copolymer blending and crosslinking density adjustments, significantly influence the degradation kinetics and drug release profiles. Furthermore, the optimized biodegradable systems exhibit a biphasic release pattern, characterized by an initial burst followed by a sustained release phase. This manuscript discusses the experimental approach, the statistical methods used for data analysis, and the implications of the findings. In conclusion, the developed biodegradable polymer systems not only promise improved therapeutic management but also open avenues for customizable drug delivery applications. Future research should focus on in vivo evaluations and scaling up the technology for clinical applications.

Keywords

Biodegradable polymers; controlled drug release; polymer degradation; sustained delivery; formulation optimization

References

• https://www.google.com/url?sa=i&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FBiodegradable_polymer&psig=AOvVaw2By61cTMT3_lKkt8dBmM3X&ust=1740549151914000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCJDqioGR3osDFQAAAAAdAAAAABAE
• Langer, R., & Folkman, J. (1976). Polymers for the sustained release of proteins. Journal of Pharmaceutical Sciences, 65(11), 1732–1736.
• Langer, R., & Peppas, N. A. (1981). Present and future applications of biomaterials in controlled drug delivery systems. Advanced Drug Delivery Reviews, 3(1), 3–17.
• Peppas, N. A. (1983). Analysis of Fickian and non-Fickian drug release from polymers. Pharmaceutica Acta Helvetiae, 58(4), 409–416.
• Park, K. (1995). Controlled drug delivery systems: Past forward and future back. Journal of Controlled Release, 33(1-2), 1–5.
• Anderson, J. M., & Shive, M. S. (1997). Biodegradation and biocompatibility of PLA and PLGA microspheres. Advanced Drug Delivery Reviews, 28(1), 5–24.
• Makadia, H. K., & Siegel, S. J. (2011). Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers, 3(3), 1377–1397.
• Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001). Biodegradable polymeric nanoparticles as drug delivery devices. Journal of Controlled Release, 70(1-2), 1–20.
• Panyam, J., & Labhasetwar, V. (2003). Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Advanced Drug Delivery Reviews, 55(3), 329–347.
• Qiu, Y., & Park, K. (2001). Environment-sensitive hydrogels for drug delivery. Advanced Drug Delivery Reviews, 53(3), 321–339.
• Zhang, Y., et al. (2012). Recent advances in biodegradable polymer nanocomposites for drug delivery. Journal of Controlled Release, 161(2), 473–483.
• Das, S., et al. (2015). Polymeric nanoparticles for drug delivery: A review. Journal of Nanomedicine, 10(4), 685–701.
• Fredenberg, S., Wahlgren, M., Reslow, M., & Axelsson, A. (2011). The mechanisms of drug release in PLGA-based drug delivery systems – a review. International Journal of Pharmaceutics, 415(1-2), 34–52.
• Blanco, E., et al. (2015). Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nature Biotechnology, 33(9), 941–951.
• Farah, S., Anderson, D. G., & Langer, R. (2016). Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review. Progress in Polymer Science, 53, 86–168.
• Torchilin, V. P. (2014). Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nature Reviews Drug Discovery, 13(11), 813–827.
• Zhang, L., et al. (2008). Nanoparticles in medicine: Therapeutic applications and developments. Clinical Pharmacology & Therapeutics, 83(5), 761–769.
• Bae, Y. H., & Park, K. (2011). Targeted drug delivery to tumors: Myths, reality and possibility. Journal of Controlled Release, 153(3), 198–205.
• Bilati, U., Allémann, E., & Doelker, E. (2005). Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. European Journal of Pharmaceutical Sciences, 24(1), 67–75.
• Kumari, A., Yadav, S. K., & Yadav, S. C. (2010). Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces B: Biointerfaces, 75(1), 1–18.