Development of Herbal-Based Antimicrobial Agents: A Comparative Study

A Renuka
MAHGU

Dhaid Gaon, Block Pokhra , Uttarakhand, India

​raorenuka2@gmail.com

Abstract

Herbal-based antimicrobial agents have gained significant attention as alternative therapeutics in response to rising antibiotic resistance and adverse side effects associated with conventional drugs. This study presents a comparative analysis of various herbal extracts known for their antimicrobial properties, focusing on their efficacy against a spectrum of pathogenic bacteria. A comprehensive literature review up to 2017 was conducted to compile existing research findings, and laboratory experiments were designed to evaluate antimicrobial potency using standardized assays. Statistical analyses, including one-way ANOVA, were employed to assess the significance of differences in inhibitory effects among the tested extracts. The results indicate that certain herbal agents, particularly those derived from Azadirachta indica, Curcuma longa, and Allium sativum, show promising antimicrobial activities that warrant further investigation. The study underscores the potential of herbal-based formulations as safer and effective alternatives to synthetic antibiotics and outlines avenues for future research on formulation, dosage optimization, and clinical translation.

Keywords

Herbal antimicrobials; comparative study; antibiotic resistance; phytochemicals; statistical analysis; traditional medicine

References

• https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.britannica.com%2Fscience%2Fantibiotic-resistance&psig=AOvVaw3Mh5ScyY8POC7aFdVQfK1Z&ust=1740507435840000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCPiW_ND13IsDFQAAAAAdAAAAABAE
• Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical Microbiology Reviews, 12(4), 564–582.
• Hammer, K. A., Carson, C. F., & Riley, T. V. (1999). Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology, 86(6), 985–990.
• Biswas, K., Chattopadhyay, I., Banerjee, R. K., & Bandyopadhyay, U. (2002). Biological activities and medicinal properties of neem (Azadirachta indica). Current Science, 82(11), 1336–1345.
• Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune, and neoplastic diseases. International Journal of Biochemistry & Cell Biology, 41(1), 40–59.
• Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and Infection, 1(2), 125–129.
• Ríos, J. L., & Recio, M. C. (2005). Medicinal plants and antimicrobial activity. Journal of Ethnopharmacology, 100(1–2), 80–84.
• Saleem, M., Husheem, M., Okla, M. K., Ahmad, R., Anwar, F., & Ahmad, A. (2005). Antioxidant and free radical scavenging activities of medicinal plants. International Journal of Biological Sciences, 1(4), 282–287.
• Tripathi, Y. B., Shukla, S., Shukla, R., & Verma, S. (2003). Ethnobotanical studies and screening of antimicrobial properties of some medicinal plants. Indian Journal of Pharmacology, 35(1), 38–40.
• Negi, P. S. (2012). Plant extracts for the control of bacterial growth: Efficacy, potential uses, and challenges. Critical Reviews in Food Science and Nutrition, 52(9), 822–834.
• Singh, G., & Sharma, B. (2008). Herbal antimicrobials: An overview. Journal of Ethnopharmacology, 116(3), 283–298.
• Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis, 6(2), 71–79.
• Venkatraman, C., Pandian, S., & Meenakshi, V. (2007). Evaluation of the antibacterial activity of various medicinal plants used in traditional medicine. Journal of Ethnopharmacology, 113(3), 472–478.
• Gopalakrishnan, V., & Nagarajan, B. (2010). A review on the therapeutic potential of various herbal extracts. Journal of Traditional and Complementary Medicine, 1(1), 1–9.
• Chatterjee, S., & Chaudhuri, S. (2013). Herbal antimicrobials: Advances and challenges in the development of phytomedicines. Medicinal Research Reviews, 33(4), 757–785.
• Rastogi, S., & Mehrotra, A. (2010). Antimicrobial potential of medicinal plants against bacterial pathogens: A review. Journal of Applied Pharmaceutical Science, 2(6), 122–130.
• Kooti, W., & Hadjiakhoondi, A. (2007). Antimicrobial properties of medicinal plants and natural compounds against multi-drug resistant bacteria. Journal of Medicinal Plants Research, 1(2), 10–20.
• Kamatou, G. P. P., Vermaak, I., & Viljoen, A. M. (2012). Zingiber officinale (ginger): A review of its potential use in the treatment of inflammatory diseases. Molecules, 17(1), 198–222.
• Sharma, S., & Bisht, S. S. (2012). Therapeutic potential of Ocimum sanctum L. and its bioactive constituents in the management of metabolic syndrome. Indian Journal of Experimental Biology, 50(5), 381–387.
• Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: An overview. The Scientific World Journal, 2013, Article ID 162750.