Development of Smart Nanoparticles for Targeted Antibiotic Delivery

DOI: https://doi.org/10.63345/ijrmp.v10.i9.1

Aman Sharma

Ghaziabad, Uttar Pradesh

Abstract

Antibiotic resistance remains one of the most pressing public health challenges of our time. Traditional antibiotic delivery methods often suffer from issues such as non-specific biodistribution, suboptimal local concentrations, and unwanted side effects. This study explores the development of smart nanoparticles designed for targeted antibiotic delivery to overcome these limitations. By engineering stimuli-responsive nanoparticle systems capable of releasing encapsulated antibiotics upon encountering specific triggers in the infection microenvironment, we demonstrate a significant improvement in targeted efficacy and reduction in systemic toxicity. The manuscript presents a comprehensive review of the literature up to 2020, details the design and statistical evaluation of the nanoparticle formulations, and discusses the methodologies used for synthesis, characterization, and in vitro evaluation. Our results indicate that these smart nanoparticles can substantially improve drug delivery profiles and offer promising insights for future therapeutic applications.

Keywords

Smart nanoparticles, targeted drug delivery, antibiotic resistance, stimuli-responsive systems, nanoparticle synthesis

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