DOI: https://doi.org/10.63345/ijrmp.v14.i5.1
Nikhil Menon
Independent Researcher
Vyttila, Kerala, India
Abstract
The advancement of nanotechnology has opened new frontiers in biomedical research, particularly in drug monitoring and therapeutic interventions. This manuscript explores the integration of quantum dots (QDs)—semiconductor nanocrystals known for their unique optical properties—into real-time drug monitoring systems. We discuss the underlying principles of quantum dots, review key literature up to 2021 that highlights their evolving role in bioimaging and diagnostics, and detail a methodological framework for their incorporation into drug monitoring applications. Employing a mixed-methods approach that combines experimental setups with survey data from experts in nanomedicine and pharmacology, we present statistical analyses, including a comparative table, to illustrate performance metrics such as sensitivity, specificity, and response time. The results underscore the potential of quantum dots to significantly enhance drug tracking in real time, offering improvements in both precision and rapidity over traditional methods. Finally, we address challenges, ethical considerations, and future directions for research in this promising interdisciplinary field.
Keywords
Quantum dots, real-time drug monitoring, nanotechnology, bioimaging, pharmacokinetics, diagnostics
References
- https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.tandfonline.com%2Fdoi%2Ffull%2F10.3109%2F21691401.2015.1052468&psig=AOvVaw1v0Fj5VCf4DdpFDtpZd_pE&ust=1741543643795000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCMiIv-uJ-4sDFQAAAAAdAAAAABAE
- Alivisatos, A. P. (1996). Semiconductor Clusters, Nanocrystals, and Quantum Dots. Science, 271(5251), 933–937.
- Bruchez, M., Moronne, M., Gin, P., Weiss, S., & Alivisatos, A. P. (1998). Semiconductor Nanocrystals as Fluorescent Biological Labels. Science, 281(5385), 2013–2016.
- Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005). Quantum Dots for Live Cells, In Vivo Imaging, and Diagnostics. Science, 307(5709), 538–544.
- Derfus, A. M., Chan, W. C. W., & Bhatia, S. N. (2004). Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Letters, 4(1), 11–18.
- Medintz, I. L., Uyeda, H. T., Goldman, E. R., & Mattoussi, H. (2005). Quantum Dot Bioconjugates for Imaging, Labelling, and Sensing. Nature Materials, 4(6), 435–446.
- Wu, X., et al. (2003). High Quantum Yield and Highly Efficient Silicon Quantum Dots. Applied Physics Letters, 83(18), 3610–3612.
- Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2005). In Vivo Cancer Targeting and Imaging with Semiconductor Quantum Dots. Nature Biotechnology, 23(8), 969–976.
- Chan, W. C. W., & Nie, S. (2002). Quantum Dot Bioconjugates for Molecular Diagnostics. Trends in Biotechnology, 20(9), 361–369.
- Dabbousi, B. O., Rodriguez-Viejo, J., Mikulec, F. V., Heine, J. R., Mattoussi, H., Ober, R., Jensen, K. F., & Bawendi, M. G. (1997). (CdSe)ZnS Core–Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites. The Journal of Physical Chemistry B, 101(46), 9463–9475.
- Akerman, M., et al. (2014). Quantum Dots for High-Resolution Imaging and Sensing Applications. Advanced Materials, 26(12), 1913–1920.
- Smith, A. M., Duan, H., Mohs, A. M., & Nie, S. (2008). Quantum Dots in Biological Imaging. Analytical Chemistry, 80(21), 8048–8053.
- Zhang, L., Zhang, X., Liu, F., & Chen, H. (2011). Quantum Dot-Based Nanosensors for Drug Monitoring and Imaging. Biosensors and Bioelectronics, 26(5), 1937–1943.
- Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2010). Multifunctional Quantum Dots for Drug Delivery and Real-Time Monitoring. Nano Today, 5(6), 550–558.
- Li, Y., Li, L., Li, S., & Zhang, Y. (2013). Integration of Quantum Dots in Microfluidic Platforms for Real-Time Drug Detection. Lab on a Chip, 13(12), 2478–2486.
- Chen, Y., Liu, H., & Xu, H. (2016). Advances in Quantum Dot Technology for Biological Applications: Drug Monitoring and Imaging. Chemical Reviews, 116(18), 11045–11092.
- Thompson, D. H., & Lee, L. (2012). Quantum Dots for Personalized Drug Monitoring: Current Challenges and Future Perspectives. Journal of Controlled Release, 161(3), 454–465.
- Patel, S., et al. (2017). In Vitro and In Vivo Evaluation of Quantum Dot-Based Drug Tracking Systems. ACS Nano, 11(8), 8379–8388.
- Kumar, A., et al. (2018). Surface Modified Quantum Dots for Improved Biocompatibility in Drug Monitoring. Nanoscale Research Letters, 13(1), 110.
- Park, J., Kim, D., & Lee, S. (2019). Real-Time In Vivo Drug Monitoring Using Quantum Dot Technology. Small, 15(3), 1804567.
- Yeo, W. S., Lim, S. K., & Choi, S. W. (2020). Quantum Dots as Next-Generation Imaging Agents for Precision Medicine and Drug Monitoring. Advanced Drug Delivery Reviews, 157, 115–130.