Impact of Gut Microbiome Modulation on Drug Absorption and Efficacy

DOI: https://doi.org/10.63345/ijrmp.v10.i10.1

Vignesh Iyer

Anna Nagar, Chennai, Tamil Nadu

Abstract

Recent studies have illuminated the critical role that the gut microbiome plays in influencing drug absorption and therapeutic efficacy. The complex interplay between host enzymes, microbial metabolites, and drug biotransformation can lead to significant inter-individual differences in drug response. This manuscript explores the mechanisms by which the gut microbiota modulates drug pharmacokinetics and pharmacodynamics, reviews the literature published up to 2020, and outlines the methodology for investigating these interactions using both clinical survey data and laboratory-based analyses. A mixed-methods approach is described, including in vivo assessments, in vitro models, and statistical analyses to elucidate the correlations between microbial diversity and drug absorption profiles. The results suggest that microbiome modulation—through diet, probiotics, or antibiotics—can significantly affect drug bioavailability and efficacy, with implications for personalized medicine. The manuscript concludes with recommendations for integrating microbiome profiling into clinical practice and outlines future research directions to enhance our understanding of host-microbiome-drug interactions.

Keywords

Gut microbiome, drug absorption, pharmacokinetics, pharmacodynamics, microbiome modulation, personalized medicine

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