Nanomedicine for Non-Invasive Treatment of Neurological Disorders

DOI: https://doi.org/10.63345/ijrmp.v12.i9.2

Gauri Tiwari

Independent Researcher

Chhattisgarh, India

Abstract

Nanomedicine has emerged as a promising field in the treatment of neurological disorders. By leveraging nanoscale materials and technologies, researchers are developing non-invasive strategies to target the central nervous system with high precision and minimal side effects. This manuscript provides an in-depth review of current nanomedicine applications for neurological diseases, highlighting mechanisms of drug delivery across the blood-brain barrier, diagnostic innovations, and therapeutic interventions. Through a systematic literature review and original survey of recent clinical and preclinical studies, we present a comprehensive analysis of nanomedicine’s efficacy, safety, and potential future developments. Our statistical analysis indicates promising trends in non-invasive delivery and improved patient outcomes, suggesting that nanomedicine may soon become an integral part of neurological disorder management.

Keywords

Nanomedicine; Non-invasive treatment; Neurological disorders; Blood-brain barrier; Drug delivery; Clinical trials.

References

• https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41401-020-0429-z&psig=AOvVaw3MxB0xsd7beyGWG8thFwQ_&ust=1742137159954000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCLCj6cKtjIwDFQAAAAAdAAAAABAE
• https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.cusabio.com%2FNeuroscience%2FBlood-brain-Barrier-Permeability.html&psig=AOvVaw0sC07NE5Gu6_t7U84QX5sg&ust=1742138022455000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCPDu44KwjIwDFQAAAAAdAAAAABAv
• Chen, Y., Wang, L., Li, Y., & Zhang, X. (2020). Nanoparticle-based drug delivery systems for brain diseases: A review. Journal of Nanomedicine, 15(3), 245–258.
• Gupta, A., & Mishra, P. (2019). Advances in non-invasive nanomedicine for neurological disorders. Nanomedicine, 14(6), 875–887.
• Khan, A., & Ahmed, R. (2018). Nanocarriers in neurotherapeutics: Overcoming the blood-brain barrier. Journal of Controlled Release, 271, 100–112.
• Lee, J., Kim, S., & Park, K. (2021). Focused ultrasound and nanoparticle-mediated delivery in neurological disorders. Neuroscience Letters, 758, 135925.
• Li, H., Sun, D., & Zhao, J. (2020). Intranasal administration of nanomedicine for brain delivery. European Journal of Pharmaceutics and Biopharmaceutics, 150, 109–118.
• Liu, X., & Chen, G. (2017). Liposome-based drug delivery to the brain: Challenges and opportunities. International Journal of Nanomedicine, 12, 1903–1915.
• Martins, R., & Souza, L. (2022). Nanotechnology in the diagnosis and treatment of neurological diseases. Journal of Nanobiotechnology, 20, 12.
• Mehta, R., & Patel, V. (2019). Nanomedicine and the blood-brain barrier: A review of recent developments. Nanotechnology Reviews, 8(4), 401–416.
• Mishra, R., & Gupta, N. (2021). Carbon nanotubes for neurological disorder treatment. Nanomedicine, 16(8), 1273–1285.
• Nguyen, T., & Lee, D. (2018). Advances in non-invasive nanomedicine for brain cancer therapy. Nanomedicine, 13(9), 913–924.
• Patel, M., & Sharma, V. (2020). Polymeric nanoparticles for targeted brain drug delivery. Journal of Drug Targeting, 28(3), 205–219.
• Reddy, K. R., & Sahoo, S. K. (2017). Nanomedicine: A new frontier for the treatment of neurological disorders. Expert Opinion on Drug Delivery, 14(11), 1505–1520.
• Roy, S., & Banerjee, S. (2019). Magnetic nanoparticles in non-invasive brain therapy. Journal of Magnetism and Magnetic Materials, 487, 165–174.
• Singh, A., & Jain, P. (2020). Advances in nanocarrier-mediated drug delivery for neurodegenerative diseases. International Journal of Pharmaceutics, 586, 119573.
• Smith, D., & Jones, M. (2022). Recent advances in theranostic nanoparticles for brain disorders. Journal of Nanomedicine Research, 10(1), 50–66.
• Tan, E., & Lim, W. (2021). Dendrimer-based drug delivery systems for non-invasive treatment of brain tumors. Biomaterials Science, 9(12), 4385–4397.
• Thomas, P., & Russell, B. (2018). Nanotechnology in neuroscience: Current trends and future perspectives. Frontiers in Neuroscience, 12, 564.
• Wang, Q., & Li, X. (2021). Recent progress in nanomedicine for brain disease treatment: A review. Journal of Controlled Release, 330, 190–203.
• Xu, J., & Zhao, Y. (2019). Non-invasive nanotechnology approaches for targeted delivery in neurological disorders. Journal of Nanobiotechnology, 17, 20.
• Zhang, L., & Zhou, H. (2020). Nanoparticle-mediated drug delivery for Parkinson’s disease: Advances and challenges. Journal of Parkinson’s Disease, 10(2), 389–402.