Potential of 3D-Printed Personalized Medicine for Rare Diseases

DOI: https://doi.org/10.63345/ijrmp.v12.i6.4

Arjun Patel

Independent Researcher

Gujarat, India

Abstract

Personalized medicine has become a vital tool in addressing the challenges associated with rare diseases. With the advent of 3D printing technology, there is now the potential to create bespoke drug delivery systems and tailor-made therapies that precisely meet the needs of individual patients. This manuscript examines the integration of 3D printing within personalized medicine for rare diseases. A review of the literature up to 2022 provides an understanding of the current state of research, technical challenges, and clinical applications. The study also presents a statistical analysis of the effectiveness and safety outcomes from preliminary studies, using a sample table to highlight key parameters. Finally, the manuscript outlines the methodology used in recent experimental setups, summarizes the results, and discusses both the current impact and future scope of 3D-printed personalized therapies.

Keywords

3D printing, personalized medicine, rare diseases, drug delivery, precision medicine

References

• https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS2352492823005664&psig=AOvVaw32c-MvXRfc0h7HSZjaT6tX&ust=1742232036934000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCOCJu8yPj4wDFQAAAAAdAAAAABAJ
• https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.pharmamirror.com%2Fknowledge-base%2Fpharmaceutical-dictionary%2Fapi%2F&psig=AOvVaw2cWPq1_rBudd5rBtTfVJ9P&ust=1742232552835000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCMDard2Qj4wDFQAAAAAdAAAAABAY
• Goyanes, A., Buanz, A. B., Basit, A. W., & Gaisford, S. (2015). 3D printing of oral dosage forms: Possibilities and challenges. Journal of Controlled Release, 185, 88–100.
• Khaled, S. A., Burley, J. C., Alexander, M. R., & Seifalian, A. M. (2015). Fused deposition modelling (FDM) 3D printing of drug-loaded tablets. International Journal of Pharmaceutics, 494(1-2), 23–29.
• Price, R. L., Hsu, Y.-C., & Zhang, J. (2016). 3D printing for personalized medicine: Technologies and applications. Advanced Drug Delivery Reviews, 108, 56–68.
• Thakkar, M. M., Parikh, R. B., & Upadhyay, A. (2017). 3D printing in pharmaceutical research and its impact on patient care. European Journal of Pharmaceutics and Biopharmaceutics, 117, 3–14.
• Keshavarz, M., Mehrabi, F., & Parhiz, H. (2019). Advances in 3D printed drug delivery systems for personalized medicine. Journal of Pharmaceutical Sciences, 108(7), 2398–2410.
• Zhang, J., Wang, Y., & Li, Q. (2018). Recent developments in 3D printing of pharmaceuticals: A review. Journal of Drug Delivery Science and Technology, 48, 169–177.
• Tappa, K., Giri, A. K., & Thakur, R. R. (2020). 3D printing: A novel approach to personalized drug delivery. Drug Discovery Today, 25(2), 301–308.
• Malik, A., Parmar, R. S., & Jariwala, B. (2019). Customizing drug delivery systems using 3D printing: Challenges and future perspectives. Pharmaceutics, 11(3), 123.
• Ventola, C. L. (2014). Medical applications for 3D printing: Current and projected uses. P & T, 39(10), 704–711.
• Noorani, A., Kumar, S., & Gupta, R. (2021). Regulatory and quality control aspects of 3D printed pharmaceuticals. Pharmaceutical Research, 38(5), 102.
• Sun, D., Chen, X., & Liu, Y. (2017). Design considerations for 3D printed drug dosage forms: A review. Journal of Pharmaceutical Innovation, 12(4), 321–330.
• Faedda, R., Martucci, G., & Ferraro, M. (2019). Future perspectives in 3D printing for personalized medicine. Expert Opinion on Drug Delivery, 16(5), 487–492.
• Singhal, R. P., Rathore, R., & Sharma, N. (2018). Personalized 3D printed implants and drug delivery systems for rare diseases. Journal of Personalized Medicine, 8(2), 12.
• Brown, M. B., Li, W., & Thompson, B. (2017). Tailoring drug release profiles via 3D printing. Journal of Controlled Release, 256, 142–150.
• Hoang, D., Nguyen, T., & Pham, H. (2020). Personalized medicine and 3D printing: Bridging the gap between laboratory and clinical practice. Medical Devices, 13, 75–83.
• Evans, D. G., Martin, A., & Roberts, S. (2016). 3D printing in pharmaceutical manufacturing: The road ahead. International Journal of Pharmaceutics, 505(1-2), 41–47.
• Kourouklis, D., Papadopoulos, T., & Sotiropoulou, E. (2019). Challenges in the clinical translation of 3D printed personalized medicines. Journal of Pharmaceutical Innovation, 14(3), 213–221.
• Patel, S., Mehta, R., & Desai, M. (2021). Recent trends in 3D printing technologies for drug delivery applications. Drug Development and Industrial Pharmacy, 47(3), 349–357.
• Lee, W., Park, S. Y., & Kim, D. (2020). Integration of 3D printing and digital health in personalized medicine. Frontiers in Pharmacology, 11, 108.
• Garcia, M. M., Santos, A., & Hernandez, R. (2022). The future of 3D printing in personalized drug therapy: Innovations and challenges. Advanced Healthcare Materials, 11(10), 2101538.