Potential of Nanosponges in Detoxification of Drug Overdose

DOI: https://doi.org/10.63345/ijrmp.v12.i1.4

Madhav Rao

Independent Researcher

Karnataka, India

Abstract

The dramatic rise in drug overdose cases has underscored the urgent need for innovative detoxification strategies. Nanosponges—nanoscale, porous, polymeric particles with the capacity to encapsulate a wide range of molecules—represent a novel therapeutic approach for sequestering and eliminating drugs from systemic circulation. This manuscript explores the potential of nanosponges as a detoxification agent in drug overdose scenarios. Through a comprehensive literature review up to 2022, we examine the physicochemical properties, design strategies, and mechanisms by which nanosponges can adsorb toxic compounds. The methodology section outlines experimental designs used to evaluate in vitro binding kinetics and in vivo efficacy, while the results section discusses promising outcomes including enhanced clearance of drugs, reduced tissue toxicity, and improved survival in animal overdose models. The discussion synthesizes current findings with prospective modifications to optimize these nanostructures for clinical application. Ultimately, this manuscript proposes that nanosponges offer a potent, versatile, and biocompatible platform for mitigating the systemic effects of drug overdose and encourages further translational research to harness their full potential.

Keywords

Nanosponges; Detoxification; Drug Overdose; Nanotechnology; In Vitro; In Vivo; Binding Kinetics; Clearance

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