Role of Bioelectronic Medicine in Treating Inflammatory Diseases

DOI: https://doi.org/10.63345/ijrmp.v10.i12.4

Ritu Das

Independent Researcher

Paltan Bazar, Assam, India

Abstract

Bioelectronic medicine, an emerging interdisciplinary field, harnesses electrical stimulation to modulate neural circuits and regulate immune responses. Recent advances have demonstrated that targeted neuromodulation can disrupt pro-inflammatory pathways and restore physiological balance in various inflammatory conditions. This manuscript reviews the conceptual framework, historical developments, and mechanistic insights that underlie bioelectronic approaches for inflammatory disease management. We discuss preclinical and early clinical studies that highlight the efficacy of vagus nerve stimulation and other neuromodulatory techniques in conditions such as rheumatoid arthritis, inflammatory bowel disease, and sepsis. The literature up to 2020 is systematically reviewed to outline both the promise and challenges of translating bioelectronic interventions into standard clinical practice. Through an in-depth me nhhhthodology section, we detail our approach to synthesizing available evidence, including experimental designs and outcome measures. Our results underscore significant anti-inflammatory effects linked to the modulation of neural circuits. In conclusion, we propose that further research, technological refinements, and integrative clinical trials will help realize the full potential of bioelectronic medicine as a safe, efficacious, and patient-specific therapy for inflammatory diseases.

Keywords

Bioelectronic medicine; inflammatory diseases; neuromodulation; vagus nerve stimulation; immunomodulation; clinical trials

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