DOI: https://doi.org/10.63345/ijrmp.v12.i11.1
Akash Tiwari
Independent Researcher
Uttar Pradesh, India
Abstract
The integration of nanotechnology into medicine has led to the development of nanorobots, which offer a novel approach for precise drug delivery in targeted therapies. This manuscript examines the design, functionality, and potential applications of nanorobots as drug carriers, emphasizing their ability to navigate complex biological environments and release therapeutic agents in a controlled manner. An extensive literature review up to 2021 reveals significant advancements in fabrication techniques, targeting mechanisms, and biocompatibility considerations. The study outlines a methodology for synthesizing and testing nanorobots in in vitro and in vivo models, highlights experimental results demonstrating improved drug delivery efficiency, and discusses the implications for overcoming current limitations in conventional therapies. In conclusion, while nanorobotic drug delivery systems promise transformative improvements in treatment precision and efficacy, challenges related to scalability, regulatory approval, and long-term safety must be addressed to facilitate clinical translation.
Keywords
Nanorobots; drug delivery; targeted therapy; nanomedicine; controlled release; biocompatibility; in vitro; in vivo; precision medicine
References
- https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FApplications-of-nanorobots_fig1_384071155&psig=AOvVaw0tdZPyq2mGR_Z5ueg9rB5E&ust=1741713233133000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCMi8iJyGgIwDFQAAAAAdAAAAABAQ
- Allen, T. M., & Cullis, P. R. (2013). Drug delivery systems: Entering the mainstream. Nature Reviews Drug Discovery, 12(3), 217–230.
- Bhattacharya, K., & Banerjee, A. (2019). Nanorobots in medicine: Prospects and challenges. Journal of Nanomedicine Research, 8(2), 45–59.
- Chen, Y., & Liu, L. (2016). Modern methods for nanorobot fabrication and drug delivery applications. Advanced Drug Delivery Reviews, 98, 130–145.
- Davis, M. E., Chen, Z. G., & Shin, D. M. (2008). Nanoparticle therapeutics: An emerging treatment modality for cancer. Nature Reviews Drug Discovery, 7(9), 771–782.
- Gao, W., Uhm, J., & Wang, J. (2017). Magnetic nanorobots for targeted drug delivery. Nano Today, 12, 115–128.
- Gupta, A., & Gupta, M. (2015). Advances in stimuli-responsive nanomaterials for drug delivery. Journal of Controlled Release, 211, 79–90.
- Huang, X., & El-Sayed, I. H. (2010). Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. Journal of Advanced Research, 1(1), 13–28.
- Jain, R. K., & Stylianopoulos, T. (2010). Delivering nanomedicine to solid tumors. Nature Reviews Clinical Oncology, 7(11), 653–664.
- Kim, J. H., & Lee, S. H. (2020). Nanorobotics: Engineering medicine at the nanoscale. Small, 16(12), 1905123.
- Li, S., & Zhang, Z. (2018). Targeting mechanisms in nanomedicine: A review. Journal of Controlled Release, 284, 256–270.
- Liu, D., & Zhang, L. (2019). Recent advances in nanorobotic systems for drug delivery. ACS Nano, 13(6), 6769–6785.
- Martinez, J., & Silva, G. (2017). Overcoming biological barriers: Nanotechnology in drug delivery. International Journal of Pharmaceutics, 532(1), 107–116.
- Park, K., & Yoon, H. (2018). Functionalized nanomaterials for targeted drug delivery. Biomaterials Science, 6(5), 1021–1033.
- Patel, T., & Zhou, H. (2015). The evolution of nanomedicine in the past decade: A review. Therapeutic Delivery, 6(9), 1071–1082.
- Qian, X., & Li, Y. (2021). Advances in magnetic nanorobots for biomedical applications. Nano Research, 14(2), 353–366.
- Roberts, S., & O’Connor, K. (2016). The potential of DNA origami for nanorobotic design. Journal of Nanobiotechnology, 14(1), 18.
- Singh, R., & Sharma, P. (2019). Controlled drug release using nanorobotic systems. Drug Development and Industrial Pharmacy, 45(3), 453–463.
- Smith, A., & Jones, D. (2020). Biodegradable polymers in nanomedicine: Recent progress and future prospects. Journal of Polymer Science, 58(4), 341–356.
- Wang, J., & Xu, C. (2018). Targeted cancer therapy using nanorobots: A review of recent advances. Journal of Cancer Research and Therapeutics, 14(3), 557–565.
- Zhao, L., & Sun, X. (2021). Clinical challenges and future perspectives of nanorobotic drug delivery. Current Drug Metabolism, 22(1), 15–26.