Medicine and health sciences
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Performance Dashboard Design for Clinical Trial Supply Chain Monitoring
The clinical trial supply chain (CTSC) plays a pivotal role in ensuring the success of pharmaceutical research by delivering investigational medicinal products (IMPs) efficiently to trial sites. Delays, inefficiencies, or lack of visibility can compromise trial…
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Lean Six Sigma Approaches for Optimizing Patient Flow in Retail Pharmacies
Efficient patient flow in retail pharmacy settings is critical to maintaining high levels of customer satisfaction, operational performance, and patient safety. Despite increasing prescription volumes and complex healthcare interactions, many pharmacies still suffer from process bottlenecks,…
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Leadership Styles and Conflict Resolution in Cross-Disciplinary Clinical Research Teams
Cross-disciplinary clinical research teams represent the confluence of diverse scientific backgrounds, perspectives, and operational styles, making them inherently susceptible to conflict. Effective leadership plays a crucial role in mitigating these challenges while promoting team cohesion and…
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Pharmacist-Led Medication Reconciliation to Reduce Polypharmacy Risks in Elderly Care
Polypharmacy, the concurrent use of multiple medications, is a prevalent concern among the elderly population due to the high risk of adverse drug events (ADEs), drug interactions, and medication non-adherence. This manuscript investigates the effectiveness of…
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Comparative Real-World Effectiveness of Tremfaya and Tildrakizumab in Moderate-to-Severe Plaque Psoriasis
Moderate-to-severe plaque psoriasis is a chronic, immune-mediated inflammatory skin condition characterized by well-demarcated erythematous plaques. Biologic therapies targeting specific inflammatory pathways have revolutionized psoriasis management. Guselkumab (Tremfaya) and Tildrakizumab, both IL-23p19 inhibitors, represent a class of…
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Assessing Patient-Reported Outcomes in Guselkumab Therapy: A Digital App-Based Survey Study
Guselkumab, an IL-23 inhibitor, has demonstrated clinical efficacy in managing moderate-to-severe plaque psoriasis. However, limited data exists regarding patient-reported outcomes (PROs) using real-time digital tools. This study investigates the usability and effectiveness of a mobile application…
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Long-Term Immunomodulatory Effects of Tremfaya on IL-23 Pathways in Psoriatic Arthritis: A Phase III Extension Study
Psoriatic arthritis (PsA) is a chronic, inflammatory arthropathy associated with psoriasis that manifests in diverse clinical forms and affects the joints and entheses. The interleukin-23 (IL-23)/Th17 axis plays a pivotal role in the immunopathogenesis of PsA,…
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Patient Adherence Patterns with Biannual Inclisiran Injections: A Multi-Center Real-World Study
Inclisiran, a small interfering RNA targeting PCSK9, has emerged as a transformative biannual lipid-lowering therapy with the potential to address adherence challenges common in daily and weekly statin-based regimens. This study investigates real-world patient adherence patterns…
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CRISPR-Based Gene Editing for APOE4 Suppression in Alzheimer’s Mouse Models: A Novel Therapeutic Framework
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, synaptic dysfunction, and accumulation of amyloid-beta plaques. The presence of the APOE4 allele significantly increases the risk of developing late-onset AD compared to other…
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Drug-Drug Interaction Profiling of Ensovibep in Polypharmacy Patients: A Real-World Retrospective Analysis
The rising prevalence of polypharmacy among patients, particularly those with chronic comorbidities, increases the risk of drug-drug interactions (DDIs), which can undermine therapeutic outcomes. Ensovibep, a novel anti-SARS-CoV-2 agent from the DARPin (Designed Ankyrin Repeat Proteins)…