Medicine and health sciences
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Post-Acute Outcomes in Ensovibep-Treated COVID-19 Patients: A 6-Month Prospective Observational Study
The emergence of COVID-19 demanded novel therapeutic agents to mitigate both acute infection and long-term complications. Ensovibep, a designed ankyrin repeat protein (DARPin) antiviral therapeutic, showed promising efficacy in early infection management. However, its impact on…
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AI-Assisted Diagnostics in Pediatric Dentistry: A Clinical Evaluation of Caries Detection Models
Dental caries remains one of the most prevalent chronic diseases among children globally, with early detection being critical to prevent progressive enamel and dentin damage. Pediatric dentistry faces a unique challenge in accurately diagnosing carious lesions…
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Comparative Efficacy of Nano-Hydroxyapatite and Fluoride Varnishes in Post-Orthodontic Demineralization Prevention
White spot lesions (WSLs), a common sequela of fixed orthodontic therapy, result from enamel demineralization caused by plaque accumulation around brackets and wires. Preventive measures such as fluoride varnishes have long been advocated to counteract this…
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Role of Cross-Functional Communication in Clinical Trial Success: A Multi-Stakeholder Survey
Effective cross-functional communication is vital to the success of clinical trials, especially considering the increasingly complex regulatory, scientific, and operational landscape. This study explores the impact of collaborative communication practices among diverse stakeholders such as clinical…
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Analyzing the Effectiveness of Remote Electronic Data Capture (EDC) Tools in Oral Health Research
The integration of remote Electronic Data Capture (EDC) tools into oral health research represents a major advancement in data management efficiency, accuracy, and real-time collaboration. This study investigates the effectiveness of these digital platforms by evaluating…
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Enhancing Patient Engagement and Retention in Dental Research through Interactive Educational Platforms
Patient engagement and retention are fundamental challenges in dental research, particularly in longitudinal studies where consistent participant involvement is critical for data validity. This manuscript explores the effectiveness of interactive educational platforms in addressing these challenges…
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Developing Training Programs for Entry-Level Clinical Research Professionals Using GCP and eCRF Modules
The rising complexity and regulatory oversight in clinical trials necessitate structured training programs tailored for entry-level clinical research professionals. This manuscript explores the development and implementation of training programs based on Good Clinical Practice (GCP) and…
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Ethical and Regulatory Considerations in Pediatric Dental Trials: A Case-Based Review
Pediatric dental research presents unique ethical and regulatory challenges due to the vulnerability and dependent nature of child participants. This review explores the ethical principles, regulatory frameworks, and case-based applications that govern pediatric dental clinical trials.…
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The Use of Machine Learning Algorithms to Detect Adverse Events in Real-Time from Clinical Databases
Adverse events (AEs) in clinical practice present significant challenges to patient safety, regulatory compliance, and healthcare costs. The rapid digitization of healthcare records and the emergence of electronic clinical databases have opened new avenues for leveraging…
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Impact of Clinical Data Visualization Tools on Stakeholder Decision-Making in Interventional Trials
Clinical trials generate vast volumes of complex and multidimensional data, often making it difficult for stakeholders—such as investigators, sponsors, regulators, and data monitoring committees—to make timely and informed decisions. Data visualization tools, ranging from simple dashboards…